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| Cac mo roi protein trong nao benh nhan Alzheimer. |
Cac nha nghien cuu thuoc DH Northwestern (My) vua "lat tay" mot protein trong nao la thu pham chinh cuop di tri nho cua nhung nguoi bi Alzheimer. Nho phat hien nay, ho se co them thong tin ve tien trinh phat trien cua benh cung nhu bao che cac loai thuoc co the giup benh nhan phuc hoi tri nho.
Cac chuyen gia da phat hien mo nao cua benh nhan Alzheimer co so luong cac protein tich tu de hoa tan - hay con goi la ligand goc B khuech tan dang tinh bot (ADDLs) - nhieu hon khoang 70 lan so voi nao cua nguoi binh thuong. Nghien cuu nay cung co cho mot gia thuyet moi day rang ADDLs tich tu vao giai doan dau cua can benh va vo hieu hoa chuc nang ghi nho.
ADDLs tan cong hoat dong xay dung tri nho cua cac khop than kinh - nhung diem truyen thong tin trong nao - noi cac cac neuron trao doi thong tin. Khi tac dong den cac khop than kinh, ADDLs cung tac dong den cac neuron nhung khong tieu diet chung.
"Hon chuc nam nay, gioi nghien cuu deu nghi nhung phan tu lon - cac mo soi than kinh - gay ra cac van de ve tri nho. Tuy nhien, chung toi cho rang "thu pham" chinh la ADDLs...", truong nhom nghien cuu - GS. William L Klein - cho biet trong mot thong cao bao chi. "Neu chung toi co the phat trien mot loai thuoc nham toi va trung lap hoa cac neurotoxin, qua trinh mat tri nho khong nhung co the cham lai ma con co the duoc dao nguoc va chuc nang ghi nho se tro lai hoat dong binh thuong".
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| Benh Alzheimer huy hoai cac chuc nang cua nao. |
Alzheimer la benh gay sa sut tri tue (dementia) do ton thuong chat xam cua vo nao. Benh nhan bi giam tri nho, roi loan ngon ngu, mat kha nang su dung dong tac, khong nhan biet duoc va roi loan chuc nang to chuc thuc hien nhu kha nang vach ke hoach, to chuc, sap xep trinh tu, tom tat cong viec. Benh phat trien tu tu cho toi khi tri tue benh nhan sa sut tram trong, phai nam liet giuong, khong nhan biet duoc nguoi than, khong the tu an uong va tu chu dai, tieu tien. The trang ho dan dan suy kiet, cuoi cung la tu vong do cac benh nhiem trung.
Nguoi bi Alzheimer can duoc theo doi, cham soc dac biet vi ho khong the tu phuc vu. Che do an phai du chat, bo sung cac vitamin, uong du nuoc, ve sinh than the, xoa bop, tap van dong va xoay tro nguoi thuong xuyen. Khoang 80% nguoi gia bi sa sut tri tue la do benh nay. Benh xay ra o ca nam lan nu, bat ky lua tuoi nao sau 30 tuoi, nhung dai da so phat benh vao tuoi gia (tren 65-70 tuoi).
(H.T - Theo HealthDay, tong hop)
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